The US Food and Drug Administration asked makers of hand sanitisers to add denatured alcohol to the products in order to make them less palatable in a bid to discourage people, especially children, from drinking the liquid.
The regulator's advisory follows US President Donald Trump's recent comments on whether injecting disinfectants might treat COVID-19, which raised concerns that frightened people could poison themselves with untested treatments.
"Hand sanitisers are not proven to treat COVID-19, and like other products meant for external use, are not for ingestion, inhalation, or intravenous use," FDA commissioner, Stephen Hahn said in a statement.
Demand for hand sanitisers has soared after the government and health agencies advised people to clean their hands thoroughly to discourage the spread of the new coronavirus, which has caused over 51,000 deaths in the United States.
The agency said adding denatured alcohol to hand sanitisers renders a bitter taste making the liquid less appealing for consumption.
Calls to the National Poison Data System last month related to hand sanitiser increased by 79% compared to March 2019, and a majority of them were about unintentional exposure to children aged 5 and younger, the FDA said.
The agency recommended that the products carry child safety warnings and information to get medical help upon accidental consumption.
The FDA, which in March relaxed rules to allow pharmacists to supply alcohol-based hand sanitisers without prescriptions, also said it was taking measures to help ensure continued supply of the product.
More than 1,500 new makers of alcohol-based hand sanitisers have registered with the agency as it works to improve the safety and supply of the product amid the COVID-19 pandemic, the agency said.